TY  - JOUR
N1  - Copyright of this article belongs to ASM.
ID  - open147
UR  - http://aac.asm.org/content/50/7/2428.long
IS  - 7
A1  - Srinivasan, Vijaya Bharathi
A1  - Virk, Rupinder Kaur
A1  - Kaundal, Amita
A1  - Chakraborty, Rupa
A1  - Datta, Basabjit
A1  - Ramamurthy, T
A1  - Mukhopadhyay, A K
A1  - Ghosh, Amit
Y1  - 2006/07//
N2  - The molecular mechanisms of drug resistance in 19 strains of Vibrio fluvialis isolated from 1998 to 2002 in Kolkata, India, were investigated. Class 1 integrons were detected in eight strains, and four strains were found to carry SXT integrases. In the presence of carbonyl cyanide m-chlorophenylhydrazone or reserpine, all nalidixic acid- and ciprofloxacin-resistant strains became sensitive, suggesting that drug efflux plays a major role in quinolone resistance in V. fluvialis. It was further seen that strains which had MICs of > 25 microg/ml for nalidixic acid had a sense mutation (Ser to Ile) at position 83 of the quinolone resistance-determining region of gyrA. All except one of the integron- and SXT integrase-bearing strains belonged to the same ribotype.
PB  - ASM
JF  - Antimicrobial agents and chemotherapy
VL  - 50
SN  - 0066-4804
TI  - Mechanism of drug resistance in clonally related clinical isolates of Vibrio fluvialis isolated in Kolkata, India.
SP  - 2428
AV  - restricted
EP  - 32
ER  -