creators_name: Srinivasan, Vijaya Bharathi
creators_name: Virk, Rupinder Kaur
creators_name: Kaundal, Amita
creators_name: Chakraborty, Rupa
creators_name: Datta, Basabjit
creators_name: Ramamurthy, T
creators_name: Mukhopadhyay, A K
creators_name: Ghosh, Amit
type: article
datestamp: 2012-01-09 04:23:21
lastmod: 2015-01-09 08:57:58
metadata_visibility: show
title: Mechanism of drug resistance in clonally related clinical isolates of Vibrio fluvialis isolated in Kolkata, India.
ispublished: pub
subjects: QD
full_text_status: restricted
note: Copyright of this article belongs to ASM.
abstract: The molecular mechanisms of drug resistance in 19 strains of Vibrio fluvialis isolated from 1998 to 2002 in Kolkata, India, were investigated. Class 1 integrons were detected in eight strains, and four strains were found to carry SXT integrases. In the presence of carbonyl cyanide m-chlorophenylhydrazone or reserpine, all nalidixic acid- and ciprofloxacin-resistant strains became sensitive, suggesting that drug efflux plays a major role in quinolone resistance in V. fluvialis. It was further seen that strains which had MICs of > 25 microg/ml for nalidixic acid had a sense mutation (Ser to Ile) at position 83 of the quinolone resistance-determining region of gyrA. All except one of the integron- and SXT integrase-bearing strains belonged to the same ribotype.
date: 2006-07
date_type: published
publication: Antimicrobial agents and chemotherapy
volume: 50
number: 7
publisher: ASM
pagerange: 2428-32
refereed: TRUE
issn: 0066-4804
official_url: http://aac.asm.org/content/50/7/2428.long
related_url_url: http://aac.asm.org/content/50/7/2428.long
related_url_type: pub
citation:   Srinivasan, Vijaya Bharathi and Virk, Rupinder Kaur and Kaundal, Amita and Chakraborty, Rupa and Datta, Basabjit and Ramamurthy, T and Mukhopadhyay, A K and Ghosh, Amit  (2006) Mechanism of drug resistance in clonally related clinical isolates of Vibrio fluvialis isolated in Kolkata, India.  Antimicrobial agents and chemotherapy, 50 (7).  pp. 2428-32.  ISSN 0066-4804     
document_url: http://crdd.osdd.net/open/147/1/ghosh2006.pdf