<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Structural basis for the redox sensitivity of the Mycobacterium tuberculosis SigK-RskA σ-anti-σ complex."^^ . "The host-pathogen interactions in Mycobacterium tuberculosis infection are significantly influenced by redox stimuli and alterations in the levels of secreted antigens. The extracytoplasmic function (ECF) σ factor σ(K) governs the transcription of the serodominant antigens MPT70 and MPT83. The cellular levels of σ(K) are regulated by the membrane-associated anti-σ(K) (RskA) that localizes σ(K) in an inactive complex. The crystal structure of M. tuberculosis σ(K) in complex with the cytosolic domain of RskA (RskAcyto) revealed a disulfide bridge in the -35 promoter-interaction region of σ(K). Biochemical experiments reveal that the redox potential of the disulfide-forming cysteines in σ(K) is consistent with its role as a sensor. The disulfide bond in σ(K) influences the stability of the σ(K)-RskAcyto complex but does not interfere with σ(K)-promoter DNA interactions. It is noted that these disulfide-forming cysteines are conserved across homologues, suggesting that this could be a general mechanism for redox-sensitive transcription regulation."^^ . "2014-04" . "70" . "Pt 4" . . "Malden, MA : Wiley-Blackwell"^^ . . . "Acta crystallographica. Section D, Biological crystallography"^^ . . . "13990047" . . . . . . . . . . . . . . . . . . . "Jinal"^^ . "Shukla"^^ . "Jinal Shukla"^^ . . "B"^^ . "Gopal"^^ . "B Gopal"^^ . . "Krishan Gopal"^^ . "Thakur"^^ . "Krishan Gopal Thakur"^^ . . "Radhika"^^ . "Gupta"^^ . "Radhika Gupta"^^ . . "Rajesh"^^ . "Gokhale"^^ . "Rajesh Gokhale"^^ . . . . . "HTML Summary of #1532 \n\nStructural basis for the redox sensitivity of the Mycobacterium tuberculosis SigK-RskA σ-anti-σ complex.\n\n" . "text/html" . . . "QR Microbiology"@en . .