creators_name: Tuteja, Satish K
creators_name: Sabherwal, Priyanka
creators_name: Deep, Akash
creators_name: Rastogi, Richa
creators_name: Paul, Ashok K
creators_name: Suri, C Raman
type: article
datestamp: 2015-02-09 04:56:17
lastmod: 2015-02-09 04:56:17
metadata_visibility: show
title: Biofunctionalized rebar graphene (f-RG) for label-free detection of cardiac marker troponin I.
ispublished: pub
keywords: biochip; carbon nanotubes; cardiac marker; clinical diagnostics; functionalized rebar graphene; troponin I
abstract: One-step microwave-assisted unscrolling of carbon nanotubes to form functionalized rebar graphene (f-RG) is reported. The well-characterized f-RG on an interdigitated electrode biochip in a FET configuration showed enhanced electronic properties, as demonstrated with I-V characteristics. The developed device was biofunctionalized with specific anti-cTnI antibodies exhibiting a shift of threshold voltage from -2.15 V to -0.5 V and decrease in electron mobility from 3.609 × 10(4) to 8.877 × 10(3) cm(2) V(-1) s(-1). The new sensing strategy holds great promise for its applicability in diagnostics exhibiting high sensitivity (∼ 1 pg/mL) and specificity toward cardiac marker (cTnI).
date: 2014-09-10
date_type: published
publication: ACS applied materials & interfaces
volume: 6
number: 17
publisher: Washington, D.C. : American Chemical Society
pagerange: 14767-71
refereed: TRUE
issn: 1944-8252
official_url: http://pubs.acs.org/doi/abs/10.1021/am503524e
citation:   Tuteja, Satish K and Sabherwal, Priyanka and Deep, Akash and Rastogi, Richa and Paul, Ashok K and Suri, C Raman  (2014) Biofunctionalized rebar graphene (f-RG) for label-free detection of cardiac marker troponin I.  ACS applied materials & interfaces, 6 (17).  pp. 14767-71.  ISSN 1944-8252