%0 Journal Article
%@ 1873-4324
%A Tuteja, Satish K
%A Priyanka, 
%A Bhalla, Vijayender
%A Deep, Akash
%A Paul, A K
%A Suri, C Raman
%D 2014
%F open:1545
%I     Amsterdam : Elsevier
%J Analytica chimica acta
%K Biochip; Graphene sheets; Lithium ion intercalation; Troponin I
%P 148-54
%T Graphene-gated biochip for the detection of cardiac marker Troponin I.
%U http://crdd.osdd.net/open/1545/
%V 809
%X We report lithium ion intercalation mediated efficient exfoliation of graphite to form monolithic graphene sheets which have subsequently been investigated for the development of highly sensitive label-free electrochemical detection platform for cardiac biomarker, Troponin I (cTnI). The spectroscopic and morphological analysis demonstrated the formation of defect free graphene sheets which were successfully employed to fabricate an inter-digited microdevice in a drain-source configuration on a silicon biochip. The graphene gated biochip functionalized with anti-cTnI antibodies used in label free detection of cTnI which exhibited an excellent sensitivity in the picogram range (~1 pg mL(-1)) for cTnI without the use of any enzymatic amplification that promises its potential applicability for bio-molecular detection in clinical diagnosis.