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primary topic: Graphene-gated biochip for the detection of cardiac marker Troponin I.

Graphene-gated biochip for the detection of cardiac marker Troponin I.
type: AcademicArticle
type: Article
abstract: We report lithium ion intercalation mediated efficient exfoliation of graphite to form monolithic graphene sheets which have subsequently been investigated for the development of highly sensitive label-free electrochemical detection platform for cardiac biomarker, Troponin I (cTnI). The spectroscopic and morphological analysis demonstrated the formation of defect free graphene sheets which were successfully employed to fabricate an inter-digited microdevice in a drain-source configuration on a silicon biochip. The graphene gated biochip functionalized with anti-cTnI antibodies used in label free detection of cTnI which exhibited an excellent sensitivity in the picogram range (~1 pg mL(-1)) for cTnI without the use of any enzymatic amplification that promises its potential applicability for bio-molecular detection in clinical diagnosis.
date: 2014-01-27
volume: 809
is part of: Analytica chimica acta
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository

Amsterdam : Elsevier
type: Organization

Analytica chimica acta
type: Collection
issn: 18734324

A K Paul
type: Person
given name: A K
family name: Paul

Priyanka
type: Person
family name: Priyanka

C Raman Suri
type: Person
given name: C Raman
family name: Suri

Vijayender Bhalla
type: Person
given name: Vijayender
family name: Bhalla

Satish K Tuteja
type: Person
given name: Satish K
family name: Tuteja

Akash Deep
type: Person
given name: Akash
family name: Deep

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primary topic: Graphene-gated biochip for the detection of cardiac marker Troponin I.