<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Repurposing TRASH: emergence of the enzyme organomercurial lyase from a non-catalytic zinc finger scaffold."^^ . "The mercury resistance pathway enzyme organomercurial lyase (MerB) catalyzes the conversion of organomercurials to ionic mercury (Hg(2+)). Here, we provide evidence for the emergence of this enzyme from a TRASH-like, non-enzymatic, treble-clef zinc finger ancestor by domain duplication and fusion. Surprisingly, the structure-stabilizing metal-binding core of the treble-clef appears to have been repurposed in evolution to serve a catalytic role. Novel enzymatic functions are believed to have evolved from ancestral generalist catalytic scaffolds or from already specialized enzymes with catalytic promiscuity. The emergence of MerB from a zinc finger ancestor serves as a rare example of how a novel enzyme may emerge from a non-catalytic scaffold with a related binding function."^^ . "2014-10" . "188" . "1" . . "Elsevier"^^ . . . "Journal of structural biology"^^ . . . "10958657" . . . . . . . . "Srikrishna"^^ . "Subramanian"^^ . "Srikrishna Subramanian"^^ . . "Gurmeet"^^ . "Kaur"^^ . "Gurmeet Kaur"^^ . . . . . "HTML Summary of #1561 \n\nRepurposing TRASH: emergence of the enzyme organomercurial lyase from a non-catalytic zinc finger scaffold.\n\n" . "text/html" . .