…
comment: The repository administrator has not yet configured an RDF license.
primary topic: Repurposing TRASH: emergence of the enzyme organomercurial lyase from a non-catalytic zinc finger scaffold.

Repurposing TRASH: emergence of the enzyme organomercurial lyase from a non-catalytic zinc finger scaffold.
type: AcademicArticle
type: Article
abstract: The mercury resistance pathway enzyme organomercurial lyase (MerB) catalyzes the conversion of organomercurials to ionic mercury (Hg(2+)). Here, we provide evidence for the emergence of this enzyme from a TRASH-like, non-enzymatic, treble-clef zinc finger ancestor by domain duplication and fusion. Surprisingly, the structure-stabilizing metal-binding core of the treble-clef appears to have been repurposed in evolution to serve a catalytic role. Novel enzymatic functions are believed to have evolved from ancestral generalist catalytic scaffolds or from already specialized enzymes with catalytic promiscuity. The emergence of MerB from a zinc finger ancestor serves as a rare example of how a novel enzyme may emerge from a non-catalytic scaffold with a related binding function.
date: 2014-10
volume: 188
issue: 1
is part of: Journal of structural biology
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository

Elsevier
type: Organization

Journal of structural biology
type: Collection
issn: 10958657

Srikrishna Subramanian
type: Person
given name: Srikrishna
family name: Subramanian

Gurmeet Kaur
type: Person
given name: Gurmeet
family name: Kaur

HTML Summary of #1561 Repurposing TRASH: emergence of the enzyme organomercurial lyase from a non-catalytic zinc finger scaffold.
format: text/html
primary topic: Repurposing TRASH: emergence of the enzyme organomercurial lyase from a non-catalytic zinc finger scaffold.