%0 Journal Article
%@ 1932-6203
%A Singla, Arvind K
%A Gurram, Rama Krishna
%A Chauhan, Arun
%A Khatri, Neeraj
%A Vohra, Rakesh M
%A Jolly, R S
%A Agrewala, J N
%D 2014
%F open:1564
%I San Francisco, CA : Public Library of Science
%J PloS one
%N 10
%P e107051
%T Caerulomycin A suppresses immunity by inhibiting T cell activity.
%U http://crdd.osdd.net/open/1564/
%V 9
%X Caerulomycin A (CaeA) is a known antifungal and antibiotic agent. Further, CaeA is reported to induce the expansion of regulatory T cell and prolongs the survival of skin allografts in mouse model of transplantation. In the current study, CaeA was purified and characterized from a novel species of actinomycetes, Actinoalloteichus spitiensis. The CaeA was identified for its novel immunosuppressive property by inhibiting in vitro and in vivo function of T cells.