TY - JOUR ID - open1564 UR - http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107051 IS - 10 A1 - Singla, Arvind K A1 - Gurram, Rama Krishna A1 - Chauhan, Arun A1 - Khatri, Neeraj A1 - Vohra, Rakesh M A1 - Jolly, R S A1 - Agrewala, J N Y1 - 2014/// N2 - Caerulomycin A (CaeA) is a known antifungal and antibiotic agent. Further, CaeA is reported to induce the expansion of regulatory T cell and prolongs the survival of skin allografts in mouse model of transplantation. In the current study, CaeA was purified and characterized from a novel species of actinomycetes, Actinoalloteichus spitiensis. The CaeA was identified for its novel immunosuppressive property by inhibiting in vitro and in vivo function of T cells. PB - San Francisco, CA : Public Library of Science JF - PloS one VL - 9 SN - 1932-6203 TI - Caerulomycin A suppresses immunity by inhibiting T cell activity. ER -