%A Arvind K Singla
%A Rama Krishna Gurram
%A Arun Chauhan
%A Neeraj Khatri
%A Rakesh M Vohra
%A R S Jolly
%A J N Agrewala
%J PloS one
%T Caerulomycin A suppresses immunity by inhibiting T cell activity.
%X Caerulomycin A (CaeA) is a known antifungal and antibiotic agent. Further, CaeA is reported to induce the expansion of regulatory T cell and prolongs the survival of skin allografts in mouse model of transplantation. In the current study, CaeA was purified and characterized from a novel species of actinomycetes, Actinoalloteichus spitiensis. The CaeA was identified for its novel immunosuppressive property by inhibiting in vitro and in vivo function of T cells.
%N 10
%P e107051
%V 9
%D 2014
%I San Francisco, CA : Public Library of Science
%L open1564