TY - JOUR ID - open157 UR - http://onlinelibrary.wiley.com/doi/10.1111/j.1567-1364.2005.00009.x/pdf IS - 1 A1 - Patnaik, Pratap R N2 - In large-scale fermentations with oscillating microbial cultures, noise is commonly present in the feed stream(s). As this can destabilize the oscillations and even generate chaotic behavior, noise filters are employed. Here three types of filters were compared by applying them to a noise-affected continuous culture of Saccharomyces cerevisiae with chaotic oscillations. The aim was to restore the original noise-free stable oscillations. An extended Kalman filter was found to be the least efficient, a neural filter was better and a combined hybrid filter was the best. In addition, better filtering of noise was achieved in the dilution rate than in the oxygen mass transfer coefficient. These results suggest the use of hybrid filters with the dilution rate as the manipulated variable for bioreactor control. VL - 6 TI - Hybrid filtering to rescue stable oscillations from noise-induced chaos in continuous cultures of budding yeast. AV - restricted EP - 38 N1 - Copyright of this article belongs to Wiley. Y1 - 2006/01// PB - Wiley JF - FEMS yeast research KW - oscillating culture; Saccharomyces cerevisiae; extended Kalman filter; neural filter; hybrid filter SN - 1567-1356 SP - 129 ER -