…
comment: The repository administrator has not yet configured an RDF license.
primary topic: Haemoglobins of Mycobacteria: structural features and biological functions.

Haemoglobins of Mycobacteria: structural features and biological functions.
type: AcademicArticle
type: Article
abstract: The genus Mycobacterium is comprised of Gram-positive bacteria occupying a wide range of natural habitats and includes species that range from severe intracellular pathogens to economically useful and harmless microbes. The recent upsurge in the availability of microbial genome data has shown that genes encoding haemoglobin-like proteins are ubiquitous among Mycobacteria and that multiple haemoglobins (Hbs) of different classes may be present in pathogenic and non-pathogenic species. The occurrence of truncated haemoglobins (trHbs) and flavohaemoglobins (flavoHbs) showing distinct haem active site structures and ligand-binding properties suggests that these Hbs may be playing diverse functions in the cellular metabolism of Mycobacteria. TrHbs and flavoHbs from some of the severe human pathogens such as Mycobacterium tuberculosis and Mycobacterium leprae have been studied recently and their roles in effective detoxification of reactive nitrogen and oxygen species, electron cycling, modulation of redox state of the cell and facilitation of aerobic respiration have been proposed. This multiplicity in the function of Hbs may aid these pathogens to cope with various environmental stresses and survive during their intracellular regime. This chapter provides recent updates on genomic, structural and functional aspects of Mycobacterial Hbs to address their role in Mycobacteria.
date: 2013
volume: 63
is part of: Advances in microbial physiology
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository

London : Academic Press
type: Organization

Advances in microbial physiology
type: Collection
issn: 00652911

Kanak L Dikshit
type: Person
given name: Kanak L
family name: Dikshit

Kelly S Davidge
type: Person
given name: Kelly S
family name: Davidge

HTML Summary of #1594 Haemoglobins of Mycobacteria: structural features and biological functions.
format: text/html
primary topic: Haemoglobins of Mycobacteria: structural features and biological functions.