…
comment: The repository administrator has not yet configured an RDF license.
primary topic: Immunomodulation through CD40 and TLR-4: an approach to control tuberculosis (P4516)

Immunomodulation through CD40 and TLR-4: an approach to control tuberculosis (P4516)
type: AcademicArticle
type: Article
abstract: The immune system have nature's one of the most fascinating mechanisms which continuously protects us against billions of pathogens. It operates through a very well organized network of cells that constantly rove, communicate and coordinate to protect the host. The cells of the immune system regulate through sequence of events involving myriad of molecules expressed on their surface (costimulatory molecules, toll-like receptors, etc.) and also by soluble mediators (cytokines, chemokines, defensins, complement components, etc.). Moreover, the intricate interaction of these molecules among different immune cells like T cells, B cells, dendritic cells (DCs), macrophages, etc., elicit their activation or inhibition, thereby conferring resistance against various pathogens and maintain homeostasis of the immune system. Signaling of these molecules that are expressed on the surface of immune cells can further enhance their efficacy in elimination of pathogens. The study conducted by us showed that concomitant signaling through CD40 and Toll-Like Receptor-4 augmented the production of nitric oxide and proinflammatory cytokines like IL-6, TNFa and IL-12 in Mycobacterium tuberculosis (Mtb) infected DCs. Further, activated DCs showed enhanced microbicidal function and significantly reduced the intracellular survival of Mtb. This study indicates that concomitant signaling through CD40 and TLR-4 can be employed as a therapeutic strategy to curb the intracellular growth of pathogens.
date: 2013
volume: 190
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
subject: QR180 Immunology

American Association of Immunologists, Inc. 178.12
type: Organization

Journal of Immunology
type: Collection

J N Agrewala
type: Person
given name: J N
family name: Agrewala

Nargis Khan
type: Person
given name: Nargis
family name: Khan

HTML Summary of #1595 Immunomodulation through CD40 and TLR-4: an approach to control tuberculosis (P4516)
format: text/html
primary topic: Immunomodulation through CD40 and TLR-4: an approach to control tuberculosis (P4516)

QR180 Immunology
type: Concept