TY  - JOUR
N1  - Copyright of this article belongs to OUP.
ID  - open1628
UR  - http://database.oxfordjournals.org/content/2015/bav055.long
A1  - Kaur, Karambir
A1  - Tandon, Himani
A1  - Gupta, Amit Kumar
A1  - Kumar, Manoj
Y1  - 2015///
N2  - CRISPR system is a powerful defense mechanism in bacteria and archaea to provide immunity against viruses. Recently, this process found a new application in intended targeting of the genomes. CRISPR-mediated genome editing is performed by two main components namely single guide RNA and Cas9 protein. Despite the enormous data generated in this area, there is a dearth of high throughput resource. Therefore, we have developed CrisprGE, a central hub of CRISPR/Cas-based genome editing. Presently, this database holds a total of 4680 entries of 223 unique genes from 32 model and other organisms. It encompasses information about the organism, gene, target gene sequences, genetic modification, modifications length, genome editing efficiency, cell line, assay, etc. This depository is developed using the open source LAMP (Linux Apache MYSQL PHP) server. User-friendly browsing, searching facility is integrated for easy data retrieval. It also includes useful tools like BLAST CrisprGE, BLAST NTdb and CRISPR Mapper. Considering potential utilities of CRISPR in the vast area of biology and therapeutics, we foresee this platform as an assistance to accelerate research in the burgeoning field of genome engineering.Database URL: http://crdd.osdd.net/servers/crisprge/.
PB  - Oxford University Press
JF  - Database : the journal of biological databases and curation
VL  - 2015
KW  - Genome; Database
SN  - 1758-0463
TI  - CrisprGE: a central hub of CRISPR/Cas-based genome editing.
ER  -