creators_name: Agrawal, Yamini
creators_name: Khatri, Indu
creators_name: Subramanian, Srikrishna
creators_name: Shenoy,, Belle Damodara 
type: article
datestamp: 2015-07-11 05:23:36
lastmod: 2015-07-20 06:12:05
metadata_visibility: show
title: Genome sequence, comparative analysis, and evolutionary insights into chitinases of entomopathogenic fungus Hirsutella thompsonii.
ispublished: pub
subjects: QR
keywords: glycoside hydrolase family 18;mycoinsecticide;pathogen–host interactions;phylogenetic classification;subgroups A, B, and C
note: Copyright of this article belongs to OUP.
abstract: Hirsutella thompsonii (Ht) is a fungal pathogen of acarines and the primary cause of epizootics among mites. The draft genomes of two isolates of Ht (MTCC 3556: Ht3, 34.6 Mb and MTCC 6686: Ht6, 34.7 Mb) are presented and compared with the genomes of Beauveria bassiana (Bb) ARSEF 2860 and Ophiocordyceps sinensis (Os) CO18. Comparative analysis of carbohydrate active enzymes, pathogen-host interaction genes, metabolism-associated genes, and genes involved in biosynthesis of secondary metabolites in the four genomes was carried out. Reduction in gene family sizes in Ht3 and Os as compared with Ht6 and Bb is observed. Analysis of the mating type genes in Ht reveals the presence of MAT idiomorphs which is suggestive of cryptic sexual traits in Ht. We further identify and classify putative chitinases that may function as virulence factors in fungal entomopathogens due to their role in degradation of arthropod cuticle.
date: 2015-03
date_type: published
publication: Genome biology and evolution
volume: 7
number: 3
publisher: Oxford University Press
pagerange: 916-30
refereed: TRUE
issn: 1759-6653
official_url: http://gbe.oxfordjournals.org/content/7/3/916/suppl/DC1
citation:   Agrawal, Yamini and Khatri, Indu and Subramanian, Srikrishna and Shenoy,, Belle Damodara   (2015) Genome sequence, comparative analysis, and evolutionary insights into chitinases of entomopathogenic fungus Hirsutella thompsonii.  Genome biology and evolution, 7 (3).  pp. 916-30.  ISSN 1759-6653     
document_url: http://crdd.osdd.net/open/1660/1/Subramanian%20S.%202015%20Genome%20Biol%20Evol-2015-Agrawal-916-30.pdf