creators_name: Gupta, Sudheer
creators_name: Kapoor, Pallavi
creators_name: Chaudhary, Kumardeep
creators_name: Gautam, Ankur
creators_name: Kumar, Rahul
creators_name: Raghava, G.P.S.
type: article
datestamp: 2015-07-10 04:01:35
lastmod: 2015-07-10 04:01:35
metadata_visibility: show
title: Peptide toxicity prediction.
ispublished: pub
subjects: QR
keywords: ToxinPred,Peptide,Toxicity,Webserver
note: Copyright of this article belongs to Springer.
abstract: Last decade has witnessed the revival of interest in peptides as potential therapeutics candidates. However, one of the bottlenecks in the success of therapeutic peptides in clinics is their toxicity towards eukaryotic cells. Therefore, considerable efforts have been made over the years both in wet and dry lab to overcome this limitation. With the advances in peptide synthesis, now it is possible to fine-tune the physicochemical properties of peptides by incorporating several chemical modifications and thus to optimize the peptide functionality in order to minimize the toxicity without compromising their therapeutic activity. Also various in silico tools for peptide toxicity prediction and peptide designing have been developed, which facilitates designing of therapeutic peptides with desired toxicity. In this chapter, we have discussed both wet lab and dry lab approaches used to optimize peptide toxicity. More emphasis has been given to describe the in silico method, ToxinPred, to predict the toxicity of peptide and about how to design a peptide or protein with desired toxicity by mutating minimum number of amino acids.
date: 2015
date_type: published
publication: Methods in molecular biology (Clifton, N.J.)
volume: 1268
publisher: Springer
pagerange: 143-57
refereed: TRUE
issn: 1940-6029
official_url: http://link.springer.com/protocol/10.1007%2F978-1-4939-2285-7_7
citation:   Gupta, Sudheer and Kapoor, Pallavi and Chaudhary, Kumardeep and Gautam, Ankur and Kumar, Rahul and Raghava, G.P.S.  (2015) Peptide toxicity prediction.  Methods in molecular biology (Clifton, N.J.), 1268.  pp. 143-57.  ISSN 1940-6029