creators_name: Qureshi, Abid
creators_name: Thakur, Nishant
creators_name: Monga, Isha
creators_name: Thakur, Anamika
creators_name: Kumar, Manoj
type: article
datestamp: 2015-07-20 05:22:59
lastmod: 2015-07-20 05:22:59
metadata_visibility: show
title: VIRmiRNA: a comprehensive resource for experimentally validated viral miRNAs and their targets.
ispublished: pub
subjects: QR
keywords: database;viral miRNAs
note: Copyright of this article belongs to OUP(Free)
abstract: Viral microRNAs (miRNAs) regulate gene expression of viral and/or host genes to benefit the virus. Hence, miRNAs play a key role in host-virus interactions and pathogenesis of viral diseases. Lately, miRNAs have also shown potential as important targets for the development of novel antiviral therapeutics. Although several miRNA and their target repositories are available for human and other organisms in literature, but a dedicated resource on viral miRNAs and their targets are lacking. Therefore, we have developed a comprehensive viral miRNA resource harboring information of 9133 entries in three subdatabases. This includes 1308 experimentally validated miRNA sequences with their isomiRs encoded by 44 viruses in viral miRNA ' VIRMIRNA: ' and 7283 of their target genes in ' VIRMIRTAR': . Additionally, there is information of 542 antiviral miRNAs encoded by the host against 24 viruses in antiviral miRNA ' AVIRMIR': . The web interface was developed using Linux-Apache-MySQL-PHP (LAMP) software bundle. User-friendly browse, search, advanced search and useful analysis tools are also provided on the web interface. VIRmiRNA is the first specialized resource of experimentally proven virus-encoded miRNAs and their associated targets. This database would enhance the understanding of viral/host gene regulation and may also prove beneficial in the development of antiviral therapeutics. Database URL: http://crdd.osdd.net/servers/virmirna.
date: 2014
date_type: published
publication: Database : the journal of biological databases and curation
volume: 2014
publisher: Oxford University Press
refereed: TRUE
issn: 1758-0463
official_url: http://database.oxfordjournals.org/content/2014/bau103.long
citation:   Qureshi, Abid and Thakur, Nishant and Monga, Isha and Thakur, Anamika and Kumar, Manoj  (2014) VIRmiRNA: a comprehensive resource for experimentally validated viral miRNAs and their targets.  Database : the journal of biological databases and curation, 2014.   ISSN 1758-0463