TY  - JOUR
N1  - Copyright of this article belongs to Elsevier Science.
ID  - open1693
UR  - http://www.sciencedirect.com/science/article/pii/S108495211400086X
A1  - Singh, Jagmohan
Y1  - 2014/06//
N2  - DNA replication is the fundamental process of duplication of the genetic information that is vital for survival of all living cells. The basic mechanistic steps of replication initiation, elongation and termination are conserved among bacteria, lower eukaryotes, like yeast and metazoans. However, the details of the mechanisms are different. Furthermore, there is a close coordination between chromatin assembly pathways and various components of replication machinery whereby DNA replication is coupled to "chromatin replication" during cell cycle. Thereby, various epigenetic modifications associated with different states of gene expression in differentiated cells and the related chromatin structures are faithfully propagated during the cell division through tight coupling with the DNA replication machinery. Several examples are found in lower eukaryotes like budding yeast and fission yeast with close parallels in metazoans.
PB  - Elsevier Publisher
JF  - Seminars in cell & developmental biology
VL  - 30
KW  - DNA replication; Chromatin; Epigenetic states; Chromatin assembly and remodeling factors
SN  - 1096-3634
TI  - Role of DNA replication in establishment and propagation of epigenetic states of chromatin.
SP  - 131
EP  - 43
ER  -