creators_name: Khatri, Neeraj
creators_name: Sagar, Amin
creators_name: Peddada, Nagesh
creators_name: Choudhary, Vikas
creators_name: Chopra, Bhupinder Singh
creators_name: Garg, Veena
creators_name: Garg, Renu
creators_name: Ganguly, Ashish
type: article
datestamp: 2015-07-20 03:31:32
lastmod: 2015-07-20 03:31:32
metadata_visibility: show
title: Plasma gelsolin levels decrease in diabetic state and increase upon treatment with F-actin depolymerizing versions of gelsolin.
ispublished: pub
subjects: QR
keywords: Gelsolin
note: Copyright © 2014 Neeraj Khatri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
abstract: The study aims to map plasma gelsolin (pGSN) levels in diabetic humans and mice models of type II diabetes and to evaluate the efficacy of gelsolin therapy in improvement of diabetes in mice. We report that pGSN values decrease by a factor of 0.45 to 0.5 in the blood of type II diabetic humans and mice models. Oral glucose tolerance test in mice models showed that subcutaneous administration of recombinant pGSN and its F-actin depolymerizing competent versions brought down blood sugar levels comparable to Sitagliptin, a drug used to manage hyperglycemic condition. Further, daily dose of pGSN or its truncated versions to diabetic mice for a week kept sugar levels close to normal values. Also, diabetic mice treated with Sitagliptin for 7 days, showed increase in their pGSN values with the decrease in blood glucose as compared to their levels at the start of treatment. Gelsolin helped in improving glycemic control in diabetic mice. We propose that gelsolin level monitoring and replacement of F-actin severing capable gelsolin(s) should be considered in diabetic care.
date: 2014
date_type: published
publication: Journal of diabetes research
volume: 2014
publisher: Hindawi
pagerange: 152075
refereed: TRUE
issn: 2314-6753
official_url: http://www.hindawi.com/journals/jdr/2014/152075/
citation:   Khatri, Neeraj and Sagar, Amin and Peddada, Nagesh and Choudhary, Vikas and Chopra, Bhupinder Singh and Garg, Veena and Garg, Renu and Ganguly, Ashish  (2014) Plasma gelsolin levels decrease in diabetic state and increase upon treatment with F-actin depolymerizing versions of gelsolin.  Journal of diabetes research, 2014.  p. 152075.  ISSN 2314-6753