TY  - JOUR
N1  - Open Access
ID  - open1734
UR  - http://www.biologydirect.com//content/10/1/70
IS  - 1
A1  - Kaur, Gurmeet
A1  - Subramanian, Srikrishna
Y1  - 2015///
N2  - The C-terminal domain of ?-COP, an essential subunit of the COPI coatomer complex, is composed of an all ?-helical region and a small ?-sheet domain. We show that this ?-sheet domain is a Really Interesting New Gene (RING)-like treble clef zinc finger. The zinc-binding residues are substituted by other aminoacids in many homologs including the structurally-characterized proteins from Saccharomyces cerevisiae and Bos taurus. This RING-like domain is possibly related to those of other vesicle membrane-associated complexes, such as CORVET, HOPS and SEA, and likely mediates interactions with Dsl1p and assist in coat oligomerization.
PB  - BioMed Central
JF  - Biology direct
VL  - 10
SN  - 1745-6150
TI  - A novel RING finger in the C-terminal domain of the coatomer protein ?-COP.
ER  -