%A Gurmeet Kaur
%A Srikrishna Subramanian
%O Open Access
%J Biology direct
%T A novel RING finger in the C-terminal domain of the coatomer protein ?-COP.
%X The C-terminal domain of ?-COP, an essential subunit of the COPI coatomer complex, is composed of an all ?-helical region and a small ?-sheet domain. We show that this ?-sheet domain is a Really Interesting New Gene (RING)-like treble clef zinc finger. The zinc-binding residues are substituted by other aminoacids in many homologs including the structurally-characterized proteins from Saccharomyces cerevisiae and Bos taurus. This RING-like domain is possibly related to those of other vesicle membrane-associated complexes, such as CORVET, HOPS and SEA, and likely mediates interactions with Dsl1p and assist in coat oligomerization.
%N 1
%P 70
%V 10
%D 2015
%I BioMed Central
%L open1734