TY  - JOUR
N1  - Copyright of this article belongs to Elsevier Science.
ID  - open1738
UR  - http://www.sciencedirect.com/science/article/pii/S0927776515302812
A1  - Sonkusre, Praveen
A1  - Singh Cameotra, Swaranjit
Y1  - 2015/12/01/
N2  - The global issue of nosocomial infection is owing to bacterial colonization and biofilm formation on medical devices which primarily affects critically ill and/or immuno-compromised patients and also leads to malfunctioning of the devices. Therefore, it is desirable to prevent bacterial colonization on these devices by coating with a non toxic antimicrobial agent or bacterial adherence inhibitor. Here we have shown Bacillus licheniformis JS2 derived selenium nanoparticles (SeNPs) inhibit Staphylococcus aureus adherence and micro-colony formation on polystyrene, glass, and catheter surface. Results indicated that, the coating of these non toxic biogenic SeNPs, at a concentration of 0.5mgSe/ml, prohibits bacterial load to more than 60% on glass and catheter surface, when incubated at 4°C for 24h in phosphate buffered saline. Furthermore, confocal and electron microscopic observations strongly suggested the inhibition of biofilm and micro-colony formation on SeNP coated glass and catheter surfaces when cultured at 37°C for 72h in a nutrient rich medium. The study suggests that coating of biogenic SeNPs on medical devices could be an alternative approach for prevention of biofilm related infections.
PB  - Elsevier Science
JF  - Colloids and surfaces. B, Biointerfaces
VL  - 136
KW  - Adherence; Bacillus licheniformis JS2; Biofilm formation; Micro-colony; Selenium nanoparticles; Staphylococcus aureus
SN  - 1873-4367
TI  - Biogenic selenium nanoparticles inhibit Staphylococcus aureus adherence on different surfaces.
SP  - 1051
EP  - 7
ER  -