creators_name: Gupta, Ashok Kumar
creators_name: Parasar, Devraj
creators_name: Sagar, Amin
creators_name: Choudhary, Vikas
creators_name: Chopra, Bhupinder Singh
creators_name: Garg, Renu
creators_name: Ganguly, Ashish
creators_name: Khatri, Neeraj
type: article
datestamp: 2016-01-29 04:44:58
lastmod: 2016-01-29 04:44:58
metadata_visibility: show
title: Analgesic and Anti-Inflammatory Properties of Gelsolin in Acetic Acid Induced Writhing, Tail Immersion and Carrageenan Induced Paw Edema in Mice.
ispublished: pub
subjects: QR
keywords: Gelsolin; Mice
note: Open Access
abstract: Plasma gelsolin levels significantly decline in several disease conditions, since gelsolin gets scavenged when it depolymerizes and caps filamentous actin released in the circulation following tissue injury. It is well established that our body require/implement inflammatory and analgesic responses to protect against cell damage and injury to the tissue. This study was envisaged to examine analgesic and anti-inflammatory activity of exogenous gelsolin (8 mg/mouse) in mice models of pain and acute inflammation. Administration of gelsolin in acetic acid-induced writhing and tail immersion tests not only demonstrated a significant reduction in the number of acetic acid-induced writhing effects, but also exhibited an analgesic activity in tail immersion test in mice as compared to placebo treated mice. Additionally, anti-inflammatory function of gelsolin (8 mg/mouse) compared with anti-inflammatory drug diclofenac sodium (10 mg/kg)] was confirmed in the carrageenan injection induced paw edema where latter was measured by vernier caliper and fluorescent tomography imaging. Interestingly, results showed that plasma gelsolin was capable of reducing severity of inflammation in mice comparable to diclofenac sodium. Analysis of cytokines and histopathological examinations of tissue revealed administration of gelsolin and diclofenac sodium significantly reduced production of pro-inflammatory cytokines, TNF-α and IL-6. Additionally, carrageenan groups pretreated with diclofenac sodium or gelsolin showed a marked decrease in edema and infiltration of inflammatory cells in paw tissue. Our study provides evidence that administration of gelsolin can effectively reduce the pain and inflammation in mice model.
date: 2015
date_type: published
publication: PloS one
volume: 10
number: 9
publisher: Public Library of Science
pagerange: e0135558
refereed: TRUE
issn: 1932-6203
official_url: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135558
citation:   Gupta, Ashok Kumar and Parasar, Devraj and Sagar, Amin and Choudhary, Vikas and Chopra, Bhupinder Singh and Garg, Renu and Ganguly, Ashish and Khatri, Neeraj  (2015) Analgesic and Anti-Inflammatory Properties of Gelsolin in Acetic Acid Induced Writhing, Tail Immersion and Carrageenan Induced Paw Edema in Mice.  PloS one, 10 (9).  e0135558.  ISSN 1932-6203