creators_name: Kumar, Ravi
creators_name: Chaudhary, Kumardeep
creators_name: Sharma, Minakshi
creators_name: Nagpal, Gandharva
creators_name: Chauhan, Jagat Singh
creators_name: Singh, Sandeep
creators_name: Gautam, Ankur
creators_name: Raghava, G.P.S.
type: article
datestamp: 2016-01-28 09:23:52
lastmod: 2016-01-28 09:23:52
metadata_visibility: show
title: AHTPDB: a comprehensive platform for analysis and presentation of antihypertensive peptides.
ispublished: pub
subjects: QR
keywords: Bioinofrmatics
note: Open Access
abstract: AHTPDB (http://crdd.osdd.net/raghava/ahtpdb/) is a manually curated database of experimentally validated antihypertensive peptides. Information pertaining to peptides with antihypertensive activity was collected from research articles and from various peptide repositories. These peptides were derived from 35 major sources that include milk, egg, fish, pork, chicken, soybean, etc. In AHTPDB, most of the peptides belong to a family of angiotensin-I converting enzyme inhibiting peptides. The current release of AHTPDB contains 5978 peptide entries among which 1694 are unique peptides. Each entry provides detailed information about a peptide like sequence, inhibitory concentration (IC50), toxicity/bitterness value, source, length, molecular mass and information related to purification of peptides. In addition, the database provides structural information of these peptides that includes predicted tertiary and secondary structures. A user-friendly web interface with various tools has been developed to retrieve and analyse the data. It is anticipated that AHTPDB will be a useful and unique resource for the researchers working in the field of antihypertensive peptides.
date: 2015-01
date_type: published
publication: Nucleic acids research
volume: 43
number: Databa
publisher: Oxford University Press
pagerange: D956-62
refereed: TRUE
issn: 1362-4962
official_url: http://nar.oxfordjournals.org/content/43/D1/D956.long
citation:   Kumar, Ravi and Chaudhary, Kumardeep and Sharma, Minakshi and Nagpal, Gandharva and Chauhan, Jagat Singh and Singh, Sandeep and Gautam, Ankur and Raghava, G.P.S.  (2015) AHTPDB: a comprehensive platform for analysis and presentation of antihypertensive peptides.  Nucleic acids research, 43 (Databa).  D956-62.  ISSN 1362-4962