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primary topic: Challenges and solutions for a rational vaccine design for TB-endemic regions.

Challenges and solutions for a rational vaccine design for TB-endemic regions.
type: AcademicArticle
type: Article
abstract: Vaccines have been successful for global eradication or control of dreaded diseases such as smallpox, diphtheria, tetanus, yellow fever, whooping cough, polio, and measles. Unfortunately, this success has not been achieved for controlling tuberculosis (TB) worldwide. Bacillus Calmette Guérin (BCG) is the only available vaccine against TB. Paradoxically, BCG has deciphered success in the Western world but has failed in TB-endemic areas. In this article, we highlight and discuss the aspects of immunity responsible for controlling Mycobacterium tuberculosis infection and factors responsible for the failure of BCG in TB-endemic countries. In addition, we also suggest strategies that contribute toward the development of successful vaccine in protecting populations where BCG has failed.
date: 2015
volume: 41
issue: 3
is part of: Critical reviews in microbiology
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
subject: QR180 Immunology

Informa UK Ltd
type: Organization

Critical reviews in microbiology
type: Collection
issn: 15497828

Amabel C Tan
type: Person
given name: Amabel C
family name: Tan

Khurram Mushtaq
type: Person
given name: Khurram
family name: Mushtaq

Uthaman Gowthaman
type: Person
given name: Uthaman
family name: Gowthaman

Javed N Agrewala
type: Person
given name: Javed N
family name: Agrewala

David C Jackson
type: Person
given name: David C
family name: Jackson

Pradeep K Rai
type: Person
given name: Pradeep K
family name: Rai

HTML Summary of #1778 Challenges and solutions for a rational vaccine design for TB-endemic regions.
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primary topic: Challenges and solutions for a rational vaccine design for TB-endemic regions.

QR180 Immunology
type: Concept