creators_name: Gowthaman, Uthaman
creators_name: Mushtaq, Khurram
creators_name: Tan, Amabel C
creators_name: Rai, Pradeep K
creators_name: Jackson, David C
creators_name: Agrewala, Javed N
type: article
datestamp: 2016-01-28 07:21:48
lastmod: 2016-01-28 07:21:48
metadata_visibility: show
title: Challenges and solutions for a rational vaccine design for TB-endemic regions.
ispublished: pub
subjects: QR180
keywords: TB; T cell memory; Endemic areas; Vaccine; BCG
note: Copyright of this article belongs to Informa UK.
abstract: Vaccines have been successful for global eradication or control of dreaded diseases such as smallpox, diphtheria, tetanus, yellow fever, whooping cough, polio, and measles. Unfortunately, this success has not been achieved for controlling tuberculosis (TB) worldwide. Bacillus Calmette Guérin (BCG) is the only available vaccine against TB. Paradoxically, BCG has deciphered success in the Western world but has failed in TB-endemic areas. In this article, we highlight and discuss the aspects of immunity responsible for controlling Mycobacterium tuberculosis infection and factors responsible for the failure of BCG in TB-endemic countries. In addition, we also suggest strategies that contribute toward the development of successful vaccine in protecting populations where BCG has failed.
date: 2015
date_type: published
publication: Critical reviews in microbiology
volume: 41
number: 3
publisher: Informa UK Ltd
pagerange: 389-98
refereed: TRUE
issn: 1549-7828
official_url: http://www.tandfonline.com/doi/pdf/10.3109/1040841X.2013.859125
citation:   Gowthaman, Uthaman and Mushtaq, Khurram and Tan, Amabel C and Rai, Pradeep K and Jackson, David C and Agrewala, Javed N  (2015) Challenges and solutions for a rational vaccine design for TB-endemic regions.  Critical reviews in microbiology, 41 (3).  pp. 389-98.  ISSN 1549-7828