creators_name: Arora, Amit
type: article
datestamp: 2016-02-01 09:26:38
lastmod: 2016-02-01 09:26:38
metadata_visibility: show
title: MicroRNA targets: potential candidates for indirect regulation by drugs
ispublished: pub
subjects: QR
note: Copyright of this article belongs to Wolters Kluwer Health

abstract: Background: Gene expression is regulated by trans-acting transcription factors and microRNAs (miRNAs) through interactions with their respective cis-regulatory elements. The effects that drugs induce result from complex interactions in pathways downstream from their primary targets. These interactions, from gene regulatory apparatus and from drug-induced pathways, form a complex, multilayered network.

Methods: Knowing that drugs can perturb miRNA expression profiles, a genomewide analysis of drug-induced intronic miRNA perturbations has been presented here.

Results: By comparative analysis of control and drugged data sets from 27 independent gene expression experiments, it was feasible to detect the effect of drugs on miRNA target genes. Signatures of 21 of 28 miRNAs, predicted to be influenced by drug action, were detected.

Conclusion: This study demonstrates that the action of drugs on mRNA expression can be mediated through the combinatorial effects of miRNAs. In addition, transcription factors, through miRNAs within the introns of their target genes, can exert an indirect effect on the expression of distal mRNAs.

date: 2015
date_type: published
publication: Pharmacogenetics and Genomics
volume: 25
number: 3
publisher: Wolters Kluwer Health
pagerange: 107-125
id_number: doi:10.1097/FPC.0000000000000111
refereed: TRUE
issn: 1744-6872
official_url: http://dx.doi.org/10.1097/FPC.0000000000000111
citation:   Arora, Amit  (2015) MicroRNA targets: potential candidates for indirect regulation by drugs.  Pharmacogenetics and Genomics, 25 (3).  pp. 107-125.  ISSN 1744-6872