TY  - JOUR
N1  - Open Access
ID  - open1843
UR  - http://dx.doi.org/10.1155/2016/8150784
A1  - Selvaraj, MuthuKrishnan
A1  - Puri, Munish
A1  - Dikshit, Kanak L.
A1  - Lefevre, Christophe
Y1  - 2016///
N2  - The recent upsurge in microbial genome data has revealed that hemoglobin-like (HbL) proteins may be widely distributed among bacteria and that some organisms may carry more than one HbL encoding gene. However, the discovery of HbL proteins has been limited to a small number of bacteria only. This study describes the prediction of HbL proteins and their domain classification using a machine learning approach. Support vector machine (SVM) models were developed for predicting HbL proteins based upon amino acid composition (AC), dipeptide composition (DC), hybrid method (AC + DC), and position specific scoring matrix (PSSM). In addition, we introduce for the first time a new prediction method based on max to min amino acid residue (MM) profiles. The average accuracy, standard deviation (SD), false positive rate (FPR), confusion matrix, and receiver operating characteristic (ROC) were analyzed. We also compared the performance of our proposed models in homology detection databases. The performance of the different approaches was estimated using fivefold cross-validation techniques. Prediction accuracy was further investigated through confusion matrix and ROC curve analysis. All experimental results indicate that the proposed BacHbpred can be a perspective predictor for determination of HbL related proteins. BacHbpred, a web tool, has been developed for HbL prediction.
PB  - Hindawi Publishing Cop.
JF  - Advances in Bioinformatics
VL  - 2016
KW  - Bacterial Hemoglobin; Protein
SN  - 1687-8027
TI  - BacHbpred: Support Vector Machine Methods for the Prediction of Bacterial Hemoglobin-Like Proteins
SP  - 1
EP  - 11
ER  -