@article{open1855,
          volume = {197},
          number = {1},
           month = {July},
          author = {Ella Bhagyaraj and Ravikanth Nanduri and Ankita Saini and Hedwin Kitdorlang Dkhar and Nancy Ahuja and Vemika Chandra and Sahil Mahajan and Rashi Kalra and Drishti Tiwari and Charu Sharma and Ashok Kumar Janmeja and Pawan Gupta},
            note = {Copyright of this article belongs to  American Association of Immunologists},
           title = {Human Xenobiotic Nuclear Receptor PXR Augments Mycobacterium tuberculosis Survival.},
       publisher = { American Association of Immunologists},
            year = {2016},
         journal = {Journal of immunology },
           pages = {244--55},
             url = {http://crdd.osdd.net/open/1855/},
        abstract = {Mycobacterium tuberculosis can evade host defense processes, thereby ensuring its survival and pathogenesis. In this study, we investigated the role of nuclear receptor, pregnane X receptor (PXR), in M. tuberculosis infection in human monocyte-derived macrophages. In this study, we demonstrate that PXR augments M. tuberculosis survival inside the host macrophages by promoting the foamy macrophage formation and abrogating phagolysosomal fusion, inflammation, and apoptosis. Additionally, M. tuberculosis cell wall lipids, particularly mycolic acids, crosstalk with human PXR (hPXR) by interacting with its promiscuous ligand binding domain. To confirm our in vitro findings and to avoid the reported species barrier in PXR function, we adopted an in vivo mouse model expressing hPXR, wherein expression of hPXR in mice promotes M. tuberculosis survival. Therefore, pharmacological intervention and designing antagonists to hPXR may prove to be a promising adjunct therapy for tuberculosis.}
}