%A Ella Bhagyaraj
%A Ravikanth Nanduri
%A Ankita Saini
%A Hedwin Kitdorlang Dkhar
%A Nancy Ahuja
%A Vemika Chandra
%A Sahil Mahajan
%A Rashi Kalra
%A Drishti Tiwari
%A Charu Sharma
%A Ashok Kumar Janmeja
%A Pawan Gupta
%O Copyright of this article belongs to  American Association of Immunologists
%J Journal of immunology 
%T Human Xenobiotic Nuclear Receptor PXR Augments Mycobacterium tuberculosis Survival.
%X Mycobacterium tuberculosis can evade host defense processes, thereby ensuring its survival and pathogenesis. In this study, we investigated the role of nuclear receptor, pregnane X receptor (PXR), in M. tuberculosis infection in human monocyte-derived macrophages. In this study, we demonstrate that PXR augments M. tuberculosis survival inside the host macrophages by promoting the foamy macrophage formation and abrogating phagolysosomal fusion, inflammation, and apoptosis. Additionally, M. tuberculosis cell wall lipids, particularly mycolic acids, crosstalk with human PXR (hPXR) by interacting with its promiscuous ligand binding domain. To confirm our in vitro findings and to avoid the reported species barrier in PXR function, we adopted an in vivo mouse model expressing hPXR, wherein expression of hPXR in mice promotes M. tuberculosis survival. Therefore, pharmacological intervention and designing antagonists to hPXR may prove to be a promising adjunct therapy for tuberculosis.
%N 1
%P 244-55
%V 197
%D 2016
%I  American Association of Immunologists
%L open1855