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primary topic: A web-based resource for designing therapeutics against Ebola Virus.

A web-based resource for designing therapeutics against Ebola Virus.
type: AcademicArticle
type: Article
abstract: In this study, we describe a web-based resource, developed for assisting the scientific community in designing an effective therapeutics against the Ebola virus. Firstly, we predicted and identified experimentally validated epitopes in each of the antigens/proteins of the five known ebolaviruses. Secondly, we generated all the possible overlapping 9mer peptides from the proteins of ebolaviruses. Thirdly, conserved peptides across all the five ebolaviruses (four human pathogenic species) with no identical sequence in the human proteome, based on 1000 Genomes project, were identified. Finally, we identified peptide or epitope-based vaccine candidates that could activate both the B- and T-cell arms of the immune system. In addition, we also identified efficacious siRNAs against the mRNA transcriptome (absent in human transcriptome) of all the five ebolaviruses. It was observed that three species can potentially be targeted by a single siRNA (19mer) and 75 siRNAs can potentially target at least two species. A web server, EbolaVCR, has been developed that incorporates all the above information and useful computational tools (http://crdd.osdd.net/oscadd/ebola/).
date: 2016
volume: 6
is part of: Scientific reports
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: A web-based resource for designing therapeutics against Ebola Virus. (PDF)
has version: A web-based resource for designing therapeutics against Ebola Virus. (PDF)
has published: A web-based resource for designing therapeutics against Ebola Virus. (PDF)
subject: QR Microbiology

A web-based resource for designing therapeutics against Ebola Virus. (PDF)
type: Document
has file: 20.pdf
has part: 20.pdf

NPG
type: Organization

Scientific reports
type: Collection
issn: 20452322

Samir Kumar Brahmachari
type: Person
given name: Samir Kumar
family name: Brahmachari

G.P.S. Raghava
type: Person
given name: G.P.S.
family name: Raghava

Sudheer Gupta
type: Person
given name: Sudheer
family name: Gupta

Kumardeep Chaudhary
type: Person
given name: Kumardeep
family name: Chaudhary

Sandeep Kumar Dhanda
type: Person
given name: Sandeep Kumar
family name: Dhanda

HTML Summary of #1862 A web-based resource for designing therapeutics against Ebola Virus.
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primary topic: A web-based resource for designing therapeutics against Ebola Virus.

QR Microbiology
type: Concept