creators_name: Dhar, Jesmita
creators_name: Kishore, Raghuvansh
creators_name: Chakrabarti, Pinak
type: article
datestamp: 2016-09-29 10:51:35
lastmod: 2016-09-29 10:51:35
metadata_visibility: show
corp_creators: H.No. A-2, IMTECH HOUSING
title: A novel secondary structure based on fused five-membered rings motif.
ispublished: pub
subjects: QR
keywords: Protein Analysis; Structure biology
note: Open Access
abstract: An analysis of protein structures indicates the existence of a novel, fused five-membered rings motif, comprising of two residues (i and i + 1), stabilized by interresidue Ni+1-H∙∙∙Ni and intraresidue Ni+1-H∙∙∙O=Ci+1 hydrogen bonds. Fused-rings geometry is the common thread running through many commonly occurring motifs, such as β-turn, β-bulge, Asx-turn, Ser/Thr-turn, Schellman motif, and points to its structural robustness. A location close to the beginning of a β-strand is rather common for the motif. Devoid of side chain, Gly seems to be a key player in this motif, occurring at i, for which the backbone torsion angles cluster at ~(-90°, -10°) and (70°, 20°). The fused-rings structures, distant from each other in sequence, can hydrogen bond with each other, and the two segments aligned to each other in a parallel fashion, give rise to a novel secondary structure, topi, which is quite common in proteins, distinct from two major secondary structures, α-helix and β-sheet. Majority of the peptide segments making topi are identified as aggregation-prone and the residues tend to be conserved among homologous proteins.
date: 2016
date_type: published
publication: Scientific reports
volume: 6
publisher: NPG
pagerange: 31483
refereed: TRUE
issn: 2045-2322
official_url: http://www.nature.com/articles/srep31483
citation:   Dhar, Jesmita and Kishore, Raghuvansh and Chakrabarti, Pinak  (2016) A novel secondary structure based on fused five-membered rings motif.  Scientific reports, 6.  p. 31483.  ISSN 2045-2322     
document_url: http://crdd.osdd.net/open/1864/1/22.pdf