title: Managing Drug Resistance in Cancer: Role of Cancer Informatics.
creator: Gautam, Ankur
creator: Chaudhary, Kumardeep
creator: Kumar, Rahul
creator: Gupta, Sudheer
creator: Singh, Harinder
creator: Raghava, G.P.S.
subject: QR Microbiology
description: Understanding and managing cancer drug resistance is the main goal of the modern oncology programs worldwide. One of the major factors contributing to drug resistance in cancer cells is the acquired mutations in drug targets. Advances in sequencing technologies and high-throughput screening assays have generated huge information related to pharmaco-profiling of anticancer drugs and revealed the mutational spectrum of different cancers. Systematic meta-analysis of this complex data is very essential to make useful conclusions in order to manage cancer drug resistance. Bioinformatics can play a significant role to interpret this complex data into useful conclusions. In this chapter, the use of bioinformatics platforms, particularly CancerDR, in understanding the cancer drug resistance is described.
publisher: Springer
date: 2016
type: Article
type: PeerReviewed
relation: http://link.springer.com/protocol/10.1007%2F978-1-4939-3347-1_17
identifier:   Gautam, Ankur and Chaudhary, Kumardeep and Kumar, Rahul and Gupta, Sudheer and Singh, Harinder and Raghava, G.P.S.  (2016) Managing Drug Resistance in Cancer: Role of Cancer Informatics.  Methods in molecular biology (Clifton, N.J.), 1395.  pp. 299-312.  ISSN 1940-6029     
relation: http://crdd.osdd.net/open/1867/