@article{open1869, volume = {6}, author = {Amit Kumar Gupta and Karambir Kaur and Akanksha Rajput and Sandeep Kumar Dhanda and Manika Sehgal and Md Shoaib Khan and Isha Monga and Showkat Ahmad Dar and Sandeep Singh and Gandharva Nagpal and Salman Sadullah Usmani and Anamika Thakur and Gazaldeep Kaur and Shivangi Sharma and Aman Bhardwaj and Abid Qureshi and G.P.S. Raghava and Manoj Kumar}, note = {Open Access}, title = {ZikaVR: An Integrated Zika Virus Resource for Genomics, Proteomics, Phylogenetic and Therapeutic Analysis.}, publisher = {NPG}, journal = {Scientific reports}, pages = {32713}, year = {2016}, keywords = {Computational platforms and environments;Genetic databases;Genome informaticsVirology}, url = {http://crdd.osdd.net/open/1869/}, abstract = {Current Zika virus (ZIKV) outbreaks that spread in several areas of Africa, Southeast Asia, and in pacific islands is declared as a global health emergency by World Health Organization (WHO). It causes Zika fever and illness ranging from severe autoimmune to neurological complications in humans. To facilitate research on this virus, we have developed an integrative multi-omics platform; ZikaVR (http://bioinfo.imtech.res.in/manojk/zikavr/), dedicated to the ZIKV genomic, proteomic and therapeutic knowledge. It comprises of whole genome sequences, their respective functional information regarding proteins, genes, and structural content. Additionally, it also delivers sophisticated analysis such as whole-genome alignments, conservation and variation, CpG islands, codon context, usage bias and phylogenetic inferences at whole genome and proteome level with user-friendly visual environment. Further, glycosylation sites and molecular diagnostic primers were also analyzed. Most importantly, we also proposed potential therapeutically imperative constituents namely vaccine epitopes, siRNAs, miRNAs, sgRNAs and repurposing drug candidates.} }