creators_name: Gupta, Amit Kumar
creators_name: Kaur, Karambir
creators_name: Rajput, Akanksha
creators_name: Dhanda, Sandeep Kumar
creators_name: Sehgal, Manika
creators_name: Khan, Md Shoaib
creators_name: Monga, Isha
creators_name: Dar, Showkat Ahmad
creators_name: Singh, Sandeep
creators_name: Nagpal, Gandharva
creators_name: Usmani, Salman Sadullah
creators_name: Thakur, Anamika
creators_name: Kaur, Gazaldeep
creators_name: Sharma, Shivangi
creators_name: Bhardwaj, Aman
creators_name: Qureshi, Abid
creators_name: Raghava, G.P.S.
creators_name: Kumar, Manoj
type: article
datestamp: 2016-09-29 10:36:57
lastmod: 2016-09-29 10:36:57
metadata_visibility: show
title: ZikaVR: An Integrated Zika Virus Resource for Genomics, Proteomics, Phylogenetic and Therapeutic Analysis.
ispublished: pub
subjects: QR
keywords: Computational platforms and environments;Genetic databases;Genome informaticsVirology
note: Open Access
abstract: Current Zika virus (ZIKV) outbreaks that spread in several areas of Africa, Southeast Asia, and in pacific islands is declared as a global health emergency by World Health Organization (WHO). It causes Zika fever and illness ranging from severe autoimmune to neurological complications in humans. To facilitate research on this virus, we have developed an integrative multi-omics platform; ZikaVR (http://bioinfo.imtech.res.in/manojk/zikavr/), dedicated to the ZIKV genomic, proteomic and therapeutic knowledge. It comprises of whole genome sequences, their respective functional information regarding proteins, genes, and structural content. Additionally, it also delivers sophisticated analysis such as whole-genome alignments, conservation and variation, CpG islands, codon context, usage bias and phylogenetic inferences at whole genome and proteome level with user-friendly visual environment. Further, glycosylation sites and molecular diagnostic primers were also analyzed. Most importantly, we also proposed potential therapeutically imperative constituents namely vaccine epitopes, siRNAs, miRNAs, sgRNAs and repurposing drug candidates.
date: 2016
date_type: published
publication: Scientific reports
volume: 6
publisher: NPG
pagerange: 32713
refereed: TRUE
issn: 2045-2322
official_url: http://www.nature.com/articles/srep32713
citation:   Gupta, Amit Kumar and Kaur, Karambir and Rajput, Akanksha and Dhanda, Sandeep Kumar and Sehgal, Manika and Khan, Md Shoaib and Monga, Isha and Dar, Showkat Ahmad and Singh, Sandeep and Nagpal, Gandharva and Usmani, Salman Sadullah and Thakur, Anamika and Kaur, Gazaldeep and Sharma, Shivangi and Bhardwaj, Aman and Qureshi, Abid and Raghava, G.P.S. and Kumar, Manoj  (2016) ZikaVR: An Integrated Zika Virus Resource for Genomics, Proteomics, Phylogenetic and Therapeutic Analysis.  Scientific reports, 6.  p. 32713.  ISSN 2045-2322     
document_url: http://crdd.osdd.net/open/1869/1/28.pdf