creators_name: Gupta, Sudheer
creators_name: Chaudhary, Kumardeep
creators_name: Kumar, Rahul
creators_name: Gautam, Ankur
creators_name: Nanda, Jagpreet Singh
creators_name: Dhanda, Sandeep Kumar
creators_name: Brahmachari, Samir Kumar
creators_name: Raghava, G.P.S.
type: article
datestamp: 2016-09-29 10:34:44
lastmod: 2016-09-29 10:34:44
metadata_visibility: show
title: Prioritization of anticancer drugs against a cancer using genomic features of cancer cells: A step towards personalized medicine.
ispublished: pub
subjects: QR
keywords: Cancer genomicsComputational platforms and environmentsMachine learning
note: Open Access
abstract: In this study, we investigated drug profile of 24 anticancer drugs tested against a large number of cell lines in order to understand the relation between drug resistance and altered genomic features of a cancer cell line. We detected frequent mutations, high expression and high copy number variations of certain genes in both drug resistant cell lines and sensitive cell lines. It was observed that a few drugs, like Panobinostat, are effective against almost all types of cell lines, whereas certain drugs are effective against only a limited type of cell lines. Tissue-specific preference of drugs was also seen where a drug is more effective against cell lines belonging to a specific tissue. Genomic features based models have been developed for each anticancer drug and achieved average correlation between predicted and actual growth inhibition of cell lines in the range of 0.43 to 0.78. We hope, our study will throw light in the field of personalized medicine, particularly in designing patient-specific anticancer drugs. In order to serve the scientific community, a webserver, CancerDP, has been developed for predicting priority/potency of an anticancer drug against a cancer cell line using its genomic features (http://crdd.osdd.net/raghava/cancerdp/).
date: 2016
date_type: published
publication: Scientific reports
volume: 6
publisher: NPG
pagerange: 23857
refereed: TRUE
issn: 2045-2322
official_url: http://www.nature.com/articles/srep23857
citation:   Gupta, Sudheer and Chaudhary, Kumardeep and Kumar, Rahul and Gautam, Ankur and Nanda, Jagpreet Singh and Dhanda, Sandeep Kumar and Brahmachari, Samir Kumar and Raghava, G.P.S.  (2016) Prioritization of anticancer drugs against a cancer using genomic features of cancer cells: A step towards personalized medicine.  Scientific reports, 6.  p. 23857.  ISSN 2045-2322     
document_url: http://crdd.osdd.net/open/1870/1/29.pdf