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primary topic: Novel mutations conferring resistance to kanamycin in Mycobacterium tuberculosis clinical isolates from Northern India.

Novel mutations conferring resistance to kanamycin in Mycobacterium tuberculosis clinical isolates from Northern India.
type: AcademicArticle
type: Article
abstract: Twenty-nine Kanamycin resistant clinical isolates of Mycobacterium tuberculosis from Northern India were screened to evaluate genetic mutations in rrs gene, eis gene with its promoter, and whiB7 gene along with its 5'UTR. 14 strains (~48.0%) collectively exhibited mutations in rrs, eis or whiB7 target regions. While the highest frequency of mutations was found in rrs gene, eis and whiB7 loci displayed novel mutations. The novel mutations displayed by eis and whiB7 loci were found to be associated specifically with the Kanamycin resistance as none of the twenty nine Kanamycin sensitive strains harbor them. The inclusion of novel mutations of eis and whiB7 loci will be useful in improving the specificity of future diagnostics.
date: 2016-01
volume: 96
is part of: Tuberculosis (Edinburgh, Scotland)
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
subject: QR Microbiology

Elsevier Science
type: Organization

Tuberculosis (Edinburgh, Scotland)
type: Collection
issn: 1873281X

Vibhuti Rana
type: Person
given name: Vibhuti
family name: Rana

Pawan Gupta
type: Person
given name: Pawan
family name: Gupta

Shashi Anand
type: Person
given name: Shashi
family name: Anand

Charu Sharma
type: Person
given name: Charu
family name: Sharma

Amita Jain
type: Person
given name: Amita
family name: Jain

Amanpreet Kaur
type: Person
given name: Amanpreet
family name: Kaur

Garima Trivedi
type: Person
given name: Garima
family name: Trivedi

Simerpreet Kaur
type: Person
given name: Simerpreet
family name: Kaur

Pooja Singh
type: Person
given name: Pooja
family name: Singh

HTML Summary of #1916 Novel mutations conferring resistance to kanamycin in Mycobacterium tuberculosis clinical isolates from Northern India.
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primary topic: Novel mutations conferring resistance to kanamycin in Mycobacterium tuberculosis clinical isolates from Northern India.

QR Microbiology
type: Concept