TY  - JOUR
N1  - Open Access
ID  - open1975
UR  - http://dx.doi.org/10.1038/srep36617
IS  - 1
A1  - Mathur, Deepika
A1  - Prakash, Satya
A1  - Anand, Priya
A1  - Kaur, Harpreet
A1  - Agrawal, Piyush
A1  - Mehta, Ayesha
A1  - Kumar, Rajesh
A1  - Singh, Sandeep
A1  - Raghava, G.P.S.
Y1  - 2016///
N2  - Short half-life is one of the key challenges in the field of therapeutic peptides. Various studies have reported enhancement in the stability of peptides using methods like chemical modifications, D-amino acid substitution, cyclization, replacement of labile aminos acids, etc. In order to study this scattered data, there is a pressing need for a repository dedicated to the half-life of peptides. To fill this lacuna, we have developed PEPlife (http://crdd.osdd.net/raghava/peplife), a manually curated resource of experimentally determined half-life of peptides. PEPlife contains 2229 entries covering 1193 unique peptides. Each entry provides detailed information of the peptide, like its name, sequence, half-life, modifications, the experimental assay for determining half-life, biological nature and activity of the peptide. We also maintain SMILES and structures of peptides. We have incorporated web-based modules to offer user-friendly data searching and browsing in the database. PEPlife integrates numerous tools to perform various types of analysis such as BLAST, Smith-Waterman algorithm, GGSEARCH, Jalview and MUSTANG. PEPlife would augment the understanding of different factors that affect the half-life of peptides like modifications, sequence, length, route of delivery of the peptide, etc. We anticipate that PEPlife will be useful for the researchers working in the area of peptide-based therapeutics.
PB  - Nature Publishing Group
JF  - Scientific Reports
VL  - 6
SN  - 2045-2322
TI  - PEPlife: A Repository of the Half-life of Peptides
ER  -