creators_name: Sengupta, Chirantana
creators_name: Ekka, Manjula
creators_name: Arora, Saurabh
creators_name: Dhaware, Prashant D.
creators_name: Chowdhury, Rukhsana
creators_name: Raychaudhuri, Saumya
type: article
datestamp: 2018-03-24 03:38:35
lastmod: 2018-10-31 06:35:26
metadata_visibility: show
title: Cross feeding of glucose metabolism byproducts of Escherichia coli human gut isolates and probiotic strains affect survival of Vibrio cholerae
ispublished: pub
subjects: QR
keywords: V. cholerae survival, Cocultures, E. coli Nissle 1917, E. coli glucose transport mutants
note: Open Access
abstract: Vibrio cholerae converts glucose into either acid or the neutral end product acetoin and its survival in carbohydrate enriched media is linked to the nature of the byproducts produced. It has been demonstrated in this study that Escherichia coli strain isolated from the gut of healthy human volunteers and the commonly used probiotic E. coli Nissle strain that metabolize glucose to acidic byproducts drastically reduce the survival of V. cholerae strains irrespective of their glucose sensitivity and acetoin production status. Accordingly, E. coli glucose transport mutants that produce lower amounts of acidic metabolites had little effect on the survival of V. cholerae in cocultures. Thus, cross feeding of byproducts of glucose metabolism by heterologous bacteria modulates the survival of V. cholerae in glucose rich medium suggesting that composition of the gut microbiota could influence the outcome of V. cholerae infection especially when glucose based ORS is administered.
date: 2017
date_type: published
publication: Gut Pathogens
volume: 9
number: 3
publisher: The International Society for Genomic and Evolutionary Microbiology
id_number: doi:10.1186/s13099-016-0153-x
refereed: TRUE
issn: 1757-4749
official_url: http://dx.doi.org/10.1186/s13099-016-0153-x
citation:   Sengupta, Chirantana and Ekka, Manjula and Arora, Saurabh and Dhaware, Prashant D. and Chowdhury, Rukhsana and Raychaudhuri, Saumya  (2017) Cross feeding of glucose metabolism byproducts of Escherichia coli human gut isolates and probiotic strains affect survival of Vibrio cholerae.  Gut Pathogens, 9 (3).   ISSN 1757-4749