<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Evolutionary convergence and divergence in archaeal chromosomal proteins and Chromo-like domains from bacteria and eukaryotes."^^ . "SH3-fold-β-barrel domains of the chromo-like superfamily recognize epigenetic marks in eukaryotic proteins. Their provenance has been placed either in archaea, based on apparent structural similarity to chromatin-compacting Sul7d and Cren7 proteins, or in bacteria based on the presence of sequence homologs. Using sequence and structural evidence we establish that the archaeal Cren7/Sul7 proteins emerged from a zinc ribbon (ZnR) ancestor. Further, we show that the ancestral eukaryotic chromo-like domains evolved from bacterial versions, likely acquired from early endosymbioses, which already possessed an aromatic cage for recognition of modified amino-groups. These bacterial versions are part of a radiation of secreted SH3-fold domains, which spawned both chromo-like domains and classical SH3 domains in the context of peptide-recognition in the peptidoglycan or the extracellular matrix. This establishes that Cren7/Sul7 converged to a \"SH3\"-like state from a ZnR precursor via the loss of metal-chelation and acquisition of stronger hydrophobic interactions; it is unlikely to have participated in the evolution of the chromo-like domains. We show that archaea possess several Cren7/Sul7-related proteins with intact Zn-chelating ligands, which we predict to play previously unstudied roles in chromosome segregation during cell-division comparable to the PRC barrel and CdvA domain proteins."^^ . "2018-04-18" . "8" . "1" . . "Nature Publishing Group."^^ . . . "Scientific reports"^^ . . . "20452322" . . . . . . . . . . . . . . . . "Lakshminarayan M"^^ . "Iyer"^^ . "Lakshminarayan M Iyer"^^ . . "L"^^ . "Aravind"^^ . "L Aravind"^^ . . "Srikrishna"^^ . "Subramanian"^^ . "Srikrishna Subramanian"^^ . . "Gurmeet"^^ . "Kaur"^^ . "Gurmeet Kaur"^^ . . . . . "HTML Summary of #2100 \n\nEvolutionary convergence and divergence in archaeal chromosomal proteins and Chromo-like domains from bacteria and eukaryotes.\n\n" . "text/html" . . . "QR Microbiology"@en . .