title: Genome analysis of urease positive Serratia marcescens, co-producing SRT-2 and AAC(6')-Ic with multidrug efflux pumps for antimicrobial resistance. creator: Srinivasan, Vijaya Bharathi creator: Rajamohan, Govindan subject: QR Microbiology description: In this study, we present the genome sequence of Serratia marcescens SM03, recovered from a human gut in India. The final assembly consists of 26 scaffolds (4620 coding DNA sequences, 5.08 Mb, 59.6% G + C ratio) and 79 tRNA genes. Analysis identified novel genes associated with lactose utilization, virulence, P-loop GTPases involved in urease production, CFA/I fimbriae apparatus and Yersinia - type CRISPR proteins. Antibiotic susceptibility testing indicated drug tolerant phenotype and inhibition assays demonstrated involvement of extrusion in resistance. Presence of enzymes SRT-2, AAC(6')-Ic, with additional Ybh transporter and EamA-like efflux pumps signifies the genetic plasticity observed in S. marcescens SM03. publisher: Elsevier Science Ltd date: 2018-04-05 type: Article type: PeerReviewed relation: https://linkinghub.elsevier.com/retrieve/pii/S0888-7543(18)30209-X identifier: Srinivasan, Vijaya Bharathi and Rajamohan, Govindan (2018) Genome analysis of urease positive Serratia marcescens, co-producing SRT-2 and AAC(6')-Ic with multidrug efflux pumps for antimicrobial resistance. Genomics. ISSN 1089-8646 (In Press) relation: http://crdd.osdd.net/open/2102/