%A Vijaya Bharathi Srinivasan
%A Govindan Rajamohan
%O Copyright of this article belongs to Elsevier.
%J Genomics
%T Genome analysis of urease positive Serratia marcescens, co-producing SRT-2 and AAC(6')-Ic with multidrug efflux pumps for antimicrobial resistance.
%X In this study, we present the genome sequence of Serratia marcescens SM03, recovered from a human gut in India. The final assembly consists of 26 scaffolds (4620 coding DNA sequences, 5.08?Mb, 59.6% G?+?C ratio) and 79 tRNA genes. Analysis identified novel genes associated with lactose utilization, virulence, P-loop GTPases involved in urease production, CFA/I fimbriae apparatus and Yersinia - type CRISPR proteins. Antibiotic susceptibility testing indicated drug tolerant phenotype and inhibition assays demonstrated involvement of extrusion in resistance. Presence of enzymes SRT-2, AAC(6')-Ic, with additional Ybh transporter and EamA-like efflux pumps signifies the genetic plasticity observed in S. marcescens SM03.
%K ABC-type transporter; Hemolysin; Human gut sample; Indian strain; Sigma fimbriae; Yersinia-type CRISPR
%D 2018
%I Elsevier Science Ltd
%L open2102