@article{open2103,
          volume = {430},
          number = {15},
           month = {July},
          author = {Ahmad Showkat and Manoj Kumar},
            note = {Copyright of this article belongs to Elsevier.},
           title = {saRNAdb: Resource of Small Activating RNAs for Up-regulating the Gene Expression.},
       publisher = {Elsevier Science Ltd},
            year = {2018},
         journal = {Journal of molecular biology},
           pages = {2212--2218},
        keywords = {RNA activation; RNA interference; RNA-induced transcriptional activation; small activating RNA; small interfering RNA},
             url = {http://crdd.osdd.net/open/2103/},
        abstract = {RNA activation (RNAa) is the process of enhancing selective gene expression at transcriptional level using double-stranded RNAs, targeting gene promoter. These RNA molecules are usually 21 nucleotides long and termed as small activating RNAs (saRNAs). They are involved in gene regulation, epigenetics, gain-of-function studies and have potential therapeutic applications for various diseases especially cancer. RNAa is opposite to RNA interference in functionality; however, both processes share some protein machinery. There are many RNA interference centered online resources but no one for saRNAs; therefore, we developed "saRNAdb" database (http://bioinfo.imtech.res.in/manojk/sarna/). It contains 2150 manually curated saRNA entries with detailed information about their nucleotide sequences, activities, corresponding target gene, promoter and other experimental data. Besides, saRNA-promoter binding location, predicted saRNA features, tools (off-target, map) and RNAa-related proteins with their interacting partners are provided. saRNAdb is expected to assist in RNA research especially for nucleic acid-based therapeutics development.}
}