%0 Journal Article
%@ 1089-8638
%A Showkat, Ahmad
%A Kumar, Manoj
%D 2018
%F open:2103
%I Elsevier Science Ltd
%J Journal of molecular biology
%K RNA activation; RNA interference; RNA-induced transcriptional activation; small activating RNA; small interfering RNA
%N 15
%P 2212-2218
%T saRNAdb: Resource of Small Activating RNAs for Up-regulating the Gene Expression.
%U http://crdd.osdd.net/open/2103/
%V 430
%X RNA activation (RNAa) is the process of enhancing selective gene expression at transcriptional level using double-stranded RNAs, targeting gene promoter. These RNA molecules are usually 21 nucleotides long and termed as small activating RNAs (saRNAs). They are involved in gene regulation, epigenetics, gain-of-function studies and have potential therapeutic applications for various diseases especially cancer. RNAa is opposite to RNA interference in functionality; however, both processes share some protein machinery. There are many RNA interference centered online resources but no one for saRNAs; therefore, we developed "saRNAdb" database (http://bioinfo.imtech.res.in/manojk/sarna/). It contains 2150 manually curated saRNA entries with detailed information about their nucleotide sequences, activities, corresponding target gene, promoter and other experimental data. Besides, saRNA-promoter binding location, predicted saRNA features, tools (off-target, map) and RNAa-related proteins with their interacting partners are provided. saRNAdb is expected to assist in RNA research especially for nucleic acid-based therapeutics development.
%Z Copyright of this article belongs to Elsevier.