creators_name: Srinivasan, Vijaya Bharathi
creators_name: Angrasan, Mahavinod
creators_name: Chandel, Neha
creators_name: Rajamohan, Govindan
type: article
datestamp: 2018-08-09 06:00:11
lastmod: 2018-08-09 06:00:15
metadata_visibility: show
title: Genome sequence and comparative analysis of Bacillus cereus BC04, reveals genetic diversity and alterations for antimicrobial resistance.
ispublished: pub
subjects: QR
keywords: Active efflux; Antimicrobial resistance; Bacillus; Human microbiome; Indian gut isolate
note: Copyright of this article belongs to Springer.
abstract: In this study, we delineated the genome sequence of a Bacillus cereus strain BC04 isolated from a stool sample in India. The draft genome is 5.1 Mb in size and consists of total 109 scaffolds, GC content is 35.2% with 5182 coding genes. The comparative analysis with other completely sequenced genomes highlights the unique presence of genomic islands, hemolysin, capsular synthetic protein, modifying enzymes accC7 and catA15, regulators of antibiotic resistance MarR and LysR with annotated functions related to virulence, stress response, and antimicrobial resistance. Overall, this study not only signifies the genetic diversity in gut isolate BC04 in particular, but also pinpoints the presence of unique genes possessed by B. cereus which can be pertinently exploited to design novel drugs and intervention strategies for the treatment of food borne diseases.
date: 2018-07
date_type: published
publication: Functional & integrative genomics
volume: 18
number: 4
publisher: Springer
pagerange: 477-487
refereed: TRUE
issn: 1438-7948
citation:   Srinivasan, Vijaya Bharathi and Angrasan, Mahavinod and Chandel, Neha and Rajamohan, Govindan  (2018) Genome sequence and comparative analysis of Bacillus cereus BC04, reveals genetic diversity and alterations for antimicrobial resistance.  Functional & integrative genomics, 18 (4).  pp. 477-487.  ISSN 1438-7948