TY  - JOUR
N1  - Copyright of this article belongs to ASBMB.
ID  - open2105
UR  - http://www.jbc.org/content/293/25/9892.long
IS  - 25
A1  - Arya, Subhash B
A1  - Kumar, Gaurav
A1  - Kaur, Harmeet
A1  - Kaur, Amandeep
A1  - Tuli, Amit
Y1  - 2018/06/22/
N2  - DP-ibosylation factor-ike GTPase  () is a cancer-predisposing gene that has remained functionally uncharacterized to date. In this study, we report that ARL11 is endogenously expressed in mouse and human macrophages and regulates their activation in response to lipopolysaccharide (LPS) stimulation. Accordingly, depletion of ARL11 impaired both LPS-stimulated pro-inflammatory cytokine production by macrophages and their ability to control intracellular replication of  LPS-stimulated activation of extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) was substantially compromised in -silenced macrophages. In contrast, increased expression of ARL11 led to constitutive ERK1/2 phosphorylation, resulting in macrophage exhaustion. Finally, we found that ARL11 forms a complex with phospho-ERK in macrophages within minutes of LPS stimulation. Taken together, our findings establish ARL11 as a novel regulator of ERK signaling in macrophages, required for macrophage activation and immune function.
PB  - ASBMB
JF  - The Journal of biological chemistry
VL  - 293
KW  - 
ARL11; ARLTS1; GTPase; Salmonella; extracellular-signal-regulated kinase (ERK); lipopolysaccharide (LPS); macrophage; mitogen-activated protein kinase (MAPK)
SN  - 1083-351X
TI  - ARL11 regulates lipopolysaccharide-stimulated macrophage activation by promoting mitogen-activated protein kinase (MAPK) signaling.
SP  - 9892
EP  - 9909
ER  -