creators_name: Baindara, Piyush
creators_name: Korpole, Suresh
creators_name: Grover, Vishakha
type: article
datestamp: 2019-03-19 11:28:11
lastmod: 2019-03-19 11:28:11
metadata_visibility: show
title: Bacteriocins: perspective for the development of novel anticancer drugs.
ispublished: pub
subjects: QR
keywords: Anticancer; Antimicrobial peptides; Bacteriocin; Cationic; Cell lines; Lantibiotic
note: Copyright of this article belongs to Springer Nature.
abstract: Antimicrobial peptides (AMPs) from prokaryotic source also known as bacteriocins are ribosomally synthesized by bacteria belonging to different eubacterial taxonomic branches. Most of these AMPs are low molecular weight cationic membrane active peptides that disrupt membrane by forming pores in target cell membranes resulting in cell death. While these peptides known to exhibit broad-spectrum antimicrobial activity, including antibacterial and antifungal, they displayed minimal cytotoxicity to the host cells. Their antimicrobial efficacy has been demonstrated in vivo using diverse animal infection models. Therefore, we have discussed some of the promising peptides for their ability towards potential therapeutic applications. Further, some of these bacteriocins have also been reported to exhibit significant biological activity against various types of cancer cells in different experimental studies. In fact, differential cytotoxicity towards cancer cells as compared to normal cells by certain bacteriocins directs for a much focused research to utilize these compounds as novel therapeutic agents. In this review, bacteriocins that demonstrated antitumor activity against diverse cancer cell lines have been discussed emphasizing their biochemical features, selectivity against extra targets and molecular mechanisms of action.
date: 2018-12-18
date_type: published
publication: Applied microbiology and biotechnology
volume: 102
number: 24
publisher: Springer Nature
pagerange: 10393-10408
refereed: TRUE
issn: 1432-0614
official_url: https://link.springer.com/article/10.1007%2Fs00253-018-9420-8
citation:   Baindara, Piyush and Korpole, Suresh and Grover, Vishakha  (2018) Bacteriocins: perspective for the development of novel anticancer drugs.  Applied microbiology and biotechnology, 102 (24).  pp. 10393-10408.  ISSN 1432-0614