%A P R Patnaik
%O Copyright of this article belongs to Elsevier Science.
%J Biotechnology advances
%T Are microbes intelligent beings?: An assessment of cybernetic modeling.
%X Microorganisms growing in a multi-substrate medium have different and varying preferences for the various components of the medium. The preferences depend on the operating conditions and the substrates may be utilized sequentially or simultaneously. Sometimes an organism may change its preferences among substrates and/or switch between sequential and simultaneous utilization. These aspects are difficult to describe through models based on chemical and physical laws alone. Cybernetic modeling ascribes to microorganisms the ability to perceive their environment (i.e. the growth medium) and make 'intelligent' choices regarding substrate utilization to maximize an objective, which is usually the growth rate. This article reviews the development of cybernetic modeling since it began in 1982. Different workers have suggested different perspectives of how microbes make optimal use of their resources. These are discussed and future directions for improvement are indicated.
%N 4
%K Microbial growth; Metabolic modeling; Cybernetic modeling
%P 267-88
%V 18
%D 2000
%I Elsevier Science
%L open230