<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Delivery of antigen in allogeneic cells preferentially generates CD(4+) Th1 cells."^^ . "We have examined the possibility of evoking antigen-specific T cell immune response by using allogeneic cells as a source of adjuvant and also as a vehicle to deliver antigen. The mice were immunized with different preparations of antigen-pulsed allogeneic and syngeneic splenocytes. It was observed during the study that the animals immunized with antigen-pulsed mitomycin C treated allogeneic cells elicited antigen specific CD(4+) Th1 cell response. Predominant release of IL-2, interferon (IFN)-gamma and IgG2a-isotype also occurred. In contrast, mice immunized with antigen-pulsed syngeneic cells chiefly enhanced the production of interleukin (IL)-4 and IgG1-isotype. Further, allogeneic macrophages induced better T cell response than B cells or splenocytes and prominently induced the expression of B7-1 and B7-2. Immunization with antigen-pulsed macrophages provided better recall responses compared to B cells. This was manifested by the high LFA-1alpha and low CD45RB expression on T cells. Because it is already known that mitomycin C-treated cells undergo apoptosis and dendritic cells engulf apoptotic cells, we therefore propose that generation of T cell response using antigen-pulsed allogeneic cells may be due to the engulfment of these cells by dendritic cells, which may then process and present antigen entrapped in allogeneic cells to activate naive CD(4+) T cells and differentiate them to Th1 cells. This study therefore provides a rational basis for manipulating antigen-specific responses by immunizing with antigen-pulsed allogeneic cells."^^ . "2003-10" . . "134" . "1" . . "Wiley"^^ . . . "Clinical and experimental immunology"^^ . . . "00099104" . . . . . . . . . . . . . . . . "H"^^ . "Vohra"^^ . "H Vohra"^^ . . "J N"^^ . "Agrewala"^^ . "J N Agrewala"^^ . . "S"^^ . "Suvas"^^ . "S Suvas"^^ . . "V"^^ . "Singh"^^ . "V Singh"^^ . . . . . . "Delivery of antigen in allogeneic cells preferentially generates CD(4+) Th1 cells. (PDF)"^^ . . . . . "Delivery of antigen in allogeneic cells preferentially generates CD(4+) Th1 cells. (Image (PNG))"^^ . . . . . . "Delivery of antigen in allogeneic cells preferentially generates CD(4+) Th1 cells. (Image (PNG))"^^ . . . . . . "Delivery of antigen in allogeneic cells preferentially generates CD(4+) Th1 cells. (Image (PNG))"^^ . . . . . . "Delivery of antigen in allogeneic cells preferentially generates CD(4+) Th1 cells. (Image (PNG))"^^ . . . . . . "Delivery of antigen in allogeneic cells preferentially generates CD(4+) Th1 cells. (Indexer Terms)"^^ . . . . . "HTML Summary of #234 \n\nDelivery of antigen in allogeneic cells preferentially generates CD(4+) Th1 cells.\n\n" . "text/html" . . . "QR180 Immunology"@en . .