@article{open2436,
          volume = {8},
           month = {December},
          author = {Sandeep Kumar Dhanda and Pooja Vir and G.P.S. Raghava},
            note = {Open Access},
           title = {Designing of interferon-gamma inducing MHC class-II binders.},
       publisher = {BMC part of Springer Nature},
         journal = {Biology direct},
           pages = {30},
            year = {2013},
             url = {http://crdd.osdd.net/open/2436/},
        abstract = {The generation of interferon-gamma (IFN-{\ensuremath{\gamma}}) by MHC class II activated CD4+ T helper cells play a substantial contribution in the control of infections such as caused by Mycobacterium tuberculosis. In the past, numerous methods have been developed for predicting MHC class II binders that can activate T-helper cells. Best of author's knowledge, no method has been developed so far that can predict the type of cytokine will be secreted by these MHC Class II binders or T-helper epitopes. In this study, an attempt has been made to predict the IFN-{\ensuremath{\gamma}} inducing peptides. The main dataset used in this study contains 3705 IFN-{\ensuremath{\gamma}} inducing and 6728 non-IFN-{\ensuremath{\gamma}} inducing MHC class II binders. Another dataset called IFNgOnly contains 4483 IFN-{\ensuremath{\gamma}} inducing epitopes and 2160 epitopes that induce other cytokine except IFN-{\ensuremath{\gamma}}. In addition we have alternate dataset that contains IFN-{\ensuremath{\gamma}} inducing and equal number of random peptides.}
}